7144394
CASC5 Polyclonal Antibody, Bethyl Laboratories
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CASC5
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias
Protein CASC5, Cancer susceptibility candidate gene 5 protein homolog, Kinetochore-null protein 1, Casc5, Knl1
Gene Symbols
KNL1
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
Applications
Immunohistochemistry
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
Q8NG31
Gene ID (Entrez)
57082
Immunogen
Between 300 and 350
Primary or Secondary
Primary
Content And Storage
4° C
Gene
KNL1
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Description
- The recommended shelf life for this product is 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Monkey, Gorilla and Chimpanzee Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment
- Required for attachment of the kinetochores to the spindle microtubules
- Directly links BUB1 and BUB1B to kinetochores
- Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis
- Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.