7144289
CDK2 Polyclonal Antibody, Bethyl Laboratories
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CDK2
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias
p33(CDK2)
Immunogen
Between 248 and 298
Primary or Secondary
Primary
Content And Storage
4° C
Gene
CDK2
Applications
Immunohistochemistry
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human, Mouse
Gene Accession No.
P24941, P97377
Gene ID (Entrez)
1017, 12566
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
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Description
- The recommended shelf life for this product is 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rat, Sheep, Goat, Bovine, Dog, Horse, Rabbit, Pig, Golden hamster, Panda, Orangutan, Monkey, Gori p33cdk2 associates with cyclin A in human cells
- Kinase activity associated with cyclin A-cdc2 is found only in G2-phase
- Cdk2 also complexes with cyclins E, D1, and D3
- Cyclin E-cdk2 kinase is active in the G1- and S-phases of the cell cycle and is important (as does cyclin A-cdk2) for the progression from G1-to S-phase
- The levels of cyclin A-cdk2 is maximal at the G1/S transition and both cdk2 and cyclin A are found associated with DNA in the initiation complex during replication
- Rb protein acts as substrate for cdk2-cyclin E and/or cdk2-cyclin A in vivo
- Cdk2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase.