7144522
p600 Polyclonal Antibody, Bethyl Laboratories
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
p600
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
TBS with 0.1% BSA and 0.09% sodium azide
Gene Alias
600 kDa retinoblastoma protein-associated factor, KIAA0462, KIAA1307, N-recognin-4, p600, RBAF600, retinoblastoma-associated factor 600-like protein, retinoblastoma-associated factor of 600 kDa, zinc finger UBR1-type protein 1, zinc finger, UBR1 type 1, ZUBR1
Gene Symbols
UBR4
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
Applications
Immunofluorescence, Immunohistochemistry
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
Q5T4S7
Gene ID (Entrez)
23352
Immunogen
Between 5133 and 5183
Primary or Secondary
Primary
Content And Storage
4° C
Gene
UBR4
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Description
- The recommended shelf life for this product is 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Horse, Pig, Orangutan, Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon and E3 ubiquitin-protein ligase which is a component of the N-end rule pathway
- Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation
- Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization
- Regulates integrin-mediated signaling
- May play a role in activation of FAK in response to cell-matrix interactions
- Mediates ubiquitination of ACLY, leading to its subsequent degradation.