CD11a, Mouse anti-Human, Clone: BU17, Millipore Sigma™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD11a
Dilution
Flow Cytometry Analysis: A representative lot detected CD11a in Flow Cytometry applications (Baker, M.P., et. al. (1998). Blood. 92(8):2830-43).
Classification
Monoclonal
Form
Purified
Regulatory Status
RUO
Target Species
Human
Gene Alias
Integrin alpha-L;CD11 antigen-like family member A;Leukocyte adhesion glycoprotein LFA-1 alpha chain;LFA-1A;Leukocyte function-associated molecule 1 alpha chain
Gene Symbols
ITGAL;CD11A
Isotype
IgG1 κ
Purification Method
Protein G purified
Test Specificity
Clone BU17 detects CD11a in human cells. It targets an epitope with in the extracellular domain.
Clone
BU17
Applications
Flow Cytometry
Conjugate
Unconjugated
Host Species
Mouse
Research Discipline
Inflammation & Immunology
Formulation
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene ID (Entrez)
NP_002200.2
Immunogen
Waldenstrom macroglobulinemia lymphoplasmacytic cells.
Primary or Secondary
Primary
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Related Products
Description
- Anti-CD11a, clone BU17, Cat
- No
- MABF2003, is a mouse monoclonal antibody that detects CD11a and has been tested for use in Flow Cytometry
- Integrin alpha-L (UniProt: P20701; also known as CD11 antigen-like family member A, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function-associated molecule 1 alpha chain, CD11a) is encoded by the ITGAL (also known as CD11A) gene (Gene ID: 3683) in human
- Integrins are part of a family of heterodimeric transmembrane glycoproteins that recognize a variety of ligands and control numerous physiologic functions in cells
- CD11a is a single-pass type I membrane protein that noncovalently associates with beta2 integrin to forms a heterodimer and serve as a receptor for ICAM1, ICAM2, ICAM3 and ICAM4
- It is expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils, and eosinophils
- It is also involved in generation of common lymphoid progenitor cells in bone marrow
- In resting T-cells, about 40% of CD11a is constitutively phosphorylated and phosphorylation causes conformational changes needed for ligand binding and is considered to be essential for activation by some physiological agents
- CD11a is synthesized with a signal peptide (aa 1-25), which is subsequently cleaved off in the mature form
- It has a large extracellular domain (aa 26-1090), a transmembrane domain (aa 1091-1111), and a cytoplasmic domain 1112-1170)
- Three isoforms of CD11a have been described that are produced by alternative splicing.