VMAT1, Mouse anti-Mouse, Rat, Clone: N440/21, Millipore Sigma™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
VMAT1
Applications
Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Research Discipline
Neuroscience
Formulation
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1M Tris-Glycine, 0.15M NaCl, 0.05% sodium azide, pH7.4 with 0.05% sodium azide.
Gene ID (Entrez)
NP_694694.1
Immunogen
Recombinant fragment corresponding to 93 amino acids from the N-terminal first lumenal region of murine Vesicular amine transporter 1 (VMAT1).
Primary or Secondary
Primary
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Clone
N440/21
Classification
Monoclonal
Form
Purified
Regulatory Status
RUO
Target Species
Rat, Mouse
Gene Alias
Chromaffin granule amine transporter;Solute carrier family 18 member 1;Vesicular amine transporter 1;VAT1
Gene Symbols
Scl18a1;Vmat1
Isotype
IgG1 κ
Purification Method
Protein G purified
Test Specificity
Clone N440/21 specifically detects Vesicular monoamine transporter 1 (VMAT1) and does not show reactivity with VMAT2. It targets an epitope with in 93 amino acids from the N-terminal first lumenal region.
Related Products
Description
- Anti-VMAT1, clone N440 21, Cat
- No
- MABN2547, is a highly specific mouse monoclonal antibody that targets Vesicular Monoamine Transporter 1 and has been tested for use in Western Blotting
- Chromaffin granule amine transporter (UniProt: Q8R090; also known as Solute carrier family 18 member 1, Vesicular amine transporter 1, VMAT1, VAT1) is encoded by the Scl19a1 (also known as Vmat1) gene (Gene ID: 110877) in murine species
- Vesicular monoamine transporters (VMATs) are involved in presynaptic storage and release of neurotransmitters
- They are located in the presynaptic region and are involved in the transport of monoamines into storage vesicle, which are released upon arrival of an action potential
- Two structurally related, but pharmacologically distinct, VMATs have been described (VMAT1 and VMAT2) that are encoded by separate genes
- VMAT1 is a multi-pass membrane acidic glycoprotein that is found in both large dense-core vesicles and in small synaptic vesicles
- It s both C- and N-terminal regions are located in the cytosolic side of the vesicle
- VMAT1 is detected in adrenal medulla, and brain (at protein level)
- In brain, specifically found in the medulla oblongata, pons, prefrontal cortex, striatum, dentate gyrus and hippocampus
- VMAT1 is shown to play a key role in survival of hippocampal neurons and may contribute to neurocognitive deficits observed in neuropsychiatric disorders
- (Ref.: Multani, PK., et al
- (2013)
- Neurosci
- 232; 32-44).