B7-1/CD80, Rabbit anti-Human, Clone: IDEC-114 (Galiximab), Novus Biologicals™

B7-1/CD80

1 mg/mL

Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunoprecipitation, Functional Assay, Blocking Assay

Unconjugated

Rabbit

Adaptive Immunity, B Cell Development and Differentiation Markers, Cytokine Research, Immunology, Signal Transduction

PBS

941

Galiximab was prepared by immunizing cynomolgus monkeys with recombinant B7-1/CD80 antigen. The variable regions of the light and heavy chains were then cloned by being incorporated into a cassette vector (N5LG1) containing human constant region genes and subsequently transfected into the Dg44 CHO cell line (Hariharan K, 2013)

Primary

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

IDEC-114 (Galiximab)

Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunoprecipitation, Functional, Block/Neutralize

Monoclonal

Purified

RUO

Human

Activation B7-1 antigen, B7, BB1, CD28LG1, CD28LGB7-1 antigen), CD80 antigen, CD80 molecule, costimulatory factor CD80, costimulatory molecule variant IgV-CD80, CTLA-4 counter-receptor B7.1, T-lymphocyte activation antigen CD80

CD80

IgG λ

Protein A purified

Galiximab is a primatized mAb which consists of human constant and primate (cynomolgus macaque) variable regions and binds specifically to B7-1/CD80. B7-1/CD80 is a surface glycoprotein and a member of the B7 family of costimulatory molecules. B7-1/CD80 antigen regulates T cell activation (through interacting with CD28 or CD152) and is expressed transiently in antigen-presenting cells, T cells and normal B cells, and expressed consitutively on various subtypes of B-cell lymphomas.