Integrin beta 7, Rabbit anti-Human,Mouse, Clone: FIB27, Novus Biologicals™

Integrin beta 7

1 mg/mL

Flow Cytometry, Immunoprecipitation, Blocking Assay

Unconjugated

Rabbit

Signal Transduction

PBS

3695

FIB27 was prepared by immunizing rats with TK1 cells.

Primary

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

FIB27

Flow Cytometry, Immunoprecipitation, Block/Neutralize

Monoclonal

Purified

RUO

Human, Mouse

Gut homing receptor beta subunit, integrin beta 7 subunit, integrin beta-7, integrin, beta 7

ITGB7

IgG κ

Protein A purified

FIB27 binds specifically to both human and mouse Integrin beta 7 at epitope region Dl on which is involved in all a4b7-mediated adhesion events. Does not compete with DAKT32 for binding. FIB27 blocks LS722-induced TK1 cell aggregation (mAb LS722 is an activating anti-a4B7 antibody and induces aggregation via an a4B7-dependent pathway). Integrin beta 7 is one subunit is a heterodimer which makes up an intergin molecule. In the mouse beta-7 is selectively found on the majority of mature lymphocytes, whereas a small subpopulation of thymocytes and bone marrow cells express beta-7. Beta-7 is also expressed in variable amounts in CD4 T memory cells. Integrin molecules mediate cell-cell and cell-extracellular matrix adhesion and are involved in lymphocyte homing, leukocyte recruitment to inflammatory sites, myogenesis, hemopoiesis, and melanoma metastasis.