Endoglin/CD105, Rabbit anti-Mouse, Clone: MJ7/18, Novus Biologicals™
Rabbit Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Endoglin/CD105
Concentration
1 mg/mL
Applications
Western Blot, Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Conjugate
Unconjugated
Host Species
Rabbit
Research Discipline
Cancer, Cell Biology, Cellular Markers, Endothelial Cell Markers, Extracellular Matrix, Hypoxia, Immunology, Mesenchymal Stem Cell Markers, Stem Cell Markers
Formulation
PBS
Gene ID (Entrez)
2022
Immunogen
MJ7/18 was prepared by immunizing rats with inflamed mouse skin tissue. The antibody was selected immunohistologically for reactivity with endothelial cells.
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clone
MJ7/18
Dilution
Western Blot, Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Classification
Monoclonal
Form
Purified
Regulatory Status
RUO
Target Species
Mouse
Gene Alias
CD105, CD105 antigen, endoglin, ENDOsler-Rendu-Weber syndrome 1, HHT1FLJ41744, ORW, ORW1
Gene Symbols
ENG
Isotype
IgG κ
Purification Method
Protein A purified
Test Specificity
MJ7/18 binds specifically to mouse Endoglin/CD105. Endoglin/CD105 is a homodimer expressed by vascular endothelial cells. Endoglin/CD105 functions in adhesion and embryonic angiogenesis. Endoglin/CD105 is a major homodimeric glycoprotein of vascular endothelium involved in cell ahesion through integrin/RGD binding and the regulation of angiogenesis. Also acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade. Endoglin/CD105 is also required for GDF2/BMP9 signaling through SMAD1 in endothelial cells.
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Description
- Endoglin/CD105 Monoclonal specifically detects Endoglin/CD105 in Mouse samples
- It is validated for Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation.