Phospho-STAT1 (Ser727) Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Phospho-STAT1 (Ser727)
Applications
Dot Blot, Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
P42224
Gene ID (Entrez)
6772
Immunogen
This STAT1 phospho Ser727 antibody was raised against a synthetic peptide containing phospho-serine 727 of human STAT1.
Primary or Secondary
Primary
Product Type
Antibody
Concentration
Conc. Not Determined
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
whole serum with 30% glycerol and 0.035% sodium azide; pH
Gene Alias
2010005J02Rik; AA408197; BOS_1917; CANDF7; DD6G4-4; DKFZp686B04100; IMD31A; IMD31B; IMD31C; ISGF-3; LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta; OTTHUMP00000165046; OTTHUMP00000205845; Signal transducer and activator of transcription 1; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; Signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription 1-like; signal transducer and activator of transcription-1; STAT; STAT1; STAT91; transcription factor ISGF-3; Transcription factor ISGF-3 components p91/p84
Gene Symbols
STAT1
Isotype
IgG
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
STAT1
Related Products
Description
- STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors
- STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF and IL6
- STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism
- Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure
- The STAT1 gene is located on chromosome 2
- STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors
- After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes
- Among the seven STATs types, STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile
- STAT1 is activated by many different ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1)
- Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.