TCF7 Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
TCF7
Applications
Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
P36402
Gene ID (Entrez)
6932
Immunogen
This antibody was raised against a peptide within the N-terminal region of human TCF7.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
TCF7
Concentration
Lot-Specific
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias
AI465550; HMG-box; OTTHUMP00000159390; OTTHUMP00000159391; T cell factor-1; T-cell factor 1; T-cell specific; T-cell-specific transcription factor 1; Tcf1; Tcf-1; Tcf7; TCF-7; Transcription factor 7; transcription factor 7 (T-cell specific, HMG-box); transcription factor 7, T cell specific; transcription factor 7, T-cell specific
Gene Symbols
TCF7
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
Related Products
Description
- TCF7 (transcriptional factor 7) is a transcriptional activator involved in T-cell lymphocyte differentiation
- Necessary for the survival of CD4+ and CD8+ immature thymocytes
- Isoforms for TCF7 lacking the N-terminal CTNNB1 binding domain cannot fulfill this role
- TCF7 binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene
- It may also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes
- TLE1, TLE2, TLE3, and TLE4 repress transactivation mediated by TCF7 and CTNNB1.