SETD7 / SET7 Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
SETD7 / SET7
Applications
Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
Q8WTS6
Gene ID (Entrez)
80854
Immunogen
This antibody was raised against a peptide within human SETD7 / SET7.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
Setd7
Concentration
Lot-Specific
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias
1600028F23Rik; FLJ21193; H3-K4 methyltransferase; H3-K4-HMTase; H3-K4-HMTase SETD7; H3K4MT; Histone H3-K4 methyltransferase SETD7; histone H3-lysine 4-specific methyltransferase; Histone-lysine N-methyltransferase SETD7; Kiaa1717; KMT7; Lysine N-methyltransferase 7; mKIAA1717; OTTHUMP00000220049; SET domain containing (lysine methyltransferase) 7; SET domain containing lysine methyltransferase 7; SET domain-containing protein 7; Set7; SET7/9; Set9; Setd7
Gene Symbols
Setd7
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
Related Products
Description
- Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3
- H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation
- Plays a central role in the transcriptional activation of genes such as collagenase or insulin
- Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription
- Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins
- Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II
- Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation
- Also able to demethylated 'Lys-372' of p53/TP53 in vitro.