KDM4C Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
KDM4C
Applications
Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Monkey
Gene Alias
2410141F18Rik; AA517467; bA146B14.1; GASC1; GASC-1 protein; gene amplified in squamous cell carcinoma 1; Gene amplified in squamous cell carcinoma 1 protein; JHDM3C; JmjC domain-containing histone demethylation protein 3C; Jmjd2c; jumonji domain containing 2C; Jumonji domain-containing protein 2C; KDM4C; KIAA0780; lysine (K)-specific demethylase 4C; lysine demethylase 4C; Lysine-specific demethylase 4C; RP11-169L18.1; TDRD14C; tudor domain containing 14C
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
Concentration
Lot-Specific
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Immunogen
This antibody was raised against a peptide within human kDM4C.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
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Description
- Jumonji domain-containing protein 2C (JMJD2C)/ Lysine-specific demethylase 4C (KDM4C) is a histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3; thereby, playing a central role in histone code
- KDM4C does not demethylate histone H3 'Lys-4', H3 'Lys-27', or H4 'Lys-20'
- It demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residues
- There is no activity on mono- or dimethylated residues
- Demethylation of Lys residues generates formaldehyde and succinate.