Phospho-C17orf96 (Ser15) Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Phospho-C17orf96 (Ser15)
Applications
Dot Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Mouse
Gene Accession No.
Q7TNS8
Gene ID (Entrez)
103551
Immunogen
This antibody was raised against a synthetic peptide containing phospho-serine 15 of human C17orf96.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
EPOP
Concentration
Lot-Specific
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
70mM tris with 0.07mM EDTA, 105mM NaCl, 30% glycerol, 31mM glycine and 0.035% sodium azide; pH 8
Gene Alias
AA409164; AI413509; AW539173; C17orf96; C9H17orf96; chromosome 17 open reading frame 96; chromosome 9 open reading frame, human C17orf96; E13; E130012A19Rik; Elongin BC and Polycomb repressive complex 2-associated protein; Embryonic stem cell-specific PRC2 subunit p48; EPOP; ES cell-specific PRC2 subunit p48; esPRC2p48; hypothetical protein LOC691153; LOC691153; proline rich 28; Proline-rich protein 28; PRR28; RIKEN cDNA E130012A19 gene; uncharacterized protein C17orf96; uncharacterized protein C17orf96 homolog; Uncharacterized protein ENSP00000317905
Gene Symbols
EPOP
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
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Description
- Elongin BC and Polycomb repressive complex 2-associated protein (EPOP) also know as C17ORF96 is a scaffold protein that serves as a bridging partner between the PRC2/EED-EZH2 complex and the elongin BC complex
- It is required to fine tune the transcriptional status of polycomb group (PcG) target genes in embryonic stem cells (ESCs)
- C17ORF96 also plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression of PcG target genes
- It acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EED-EZH2 complex
- C17ORF96 also has interacts with USP7 and promotes deubiquitination of H2B at promoter sites.