ASH2L Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
ASH2L
Applications
ChIP Assay, ChIP sequencing (ChIP-seq), Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
Q9UBL3
Gene ID (Entrez)
9070
Immunogen
This ASH2L antibody was raised against full-length recombinant human ASH2L protein.
Primary or Secondary
Primary
Product Type
Antibody
Concentration
Conc. Not Determined
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
whole serum with 30% glycerol and 0.035% sodium azide; pH
Gene Alias
ASH 2; ASH2; ash2 (absent, small, or homeotic)-like; ash2 (absent, small, or homeotic)-like (Drosophila); ASH2 LIKE; ASH2 like histone lysine methyltransferase complex subunit; ASH2 like protein; ASH2 like, histone lysine methyltransferase complex subunit; Ash2l; ASH2L1; ASH2L2; ash2-like; ASH2-like protein; BOS_23936; Bre 2; Bre2; LOC100338600; Set1/Ash2 histone methyltransferase complex subunit ASH2
Gene Symbols
ASH2L
Isotype
IgG
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
ASH2L
Related Products
Description
- The human ASH2L gene encodes a 628 amino acid protein known as ASH2L1, or isoform 1, which contains a nuclear localization signal and PHD finger motif, suggesting that the gene product functions as a transcription regulator
- Its predicted molecular weight is 68.7kDa
- Alternative splicing results in possible isoforms at 60 kDa & 56.5 kDa)
- Human ASH2L proteins are 60% homologous to Drosophila ash2, which positively regulates expression of certain genes in early development, and contain similar, but not identical, domains, including a zinc finger motif
- Homology to mouse ASH2L is 90%
- ASH2L is predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes as well as leukemia cell lines with erythroid and megakaryocytic potential, such as K562, Hel and Dami
- Differentiation inducers (e.g
- phorbol ester and hemin) cause different expression patterns in these cell lines, suggesting that ASH2L plays a role in hematopoiesis and is associated with particular types of leukemia
- In addition ASH2L has been suggested to interact with beta-tubulin and beta-catenin.