7188591
Histone H3ac (pan-acetyl) Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Histone H3ac (pan-acetyl)
Applications
ChIP Assay, ChIP sequencing (ChIP-seq), Dot Blot, Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Immunogen
This Histone H3 acetyl antibody was raised against a peptide including acetyl-lysines contained in the N-terminal tail of histone H3.
Primary or Secondary
Primary
Product Type
Antibody
Concentration
Conc. Not Determined
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
whole serum with 30% glycerol and 0.035% sodium azide; pH
Isotype
IgG
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
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Description
- Description Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells
- H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome
- Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability
- Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors
- The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modifications that influence cellular processes
- These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.