ZEB1 Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
ZEB1
Applications
Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
P37275
Gene ID (Entrez)
6935
Immunogen
This ZEB1 antibody was raised against a peptide derived from the N-terminal region of human ZEB1.
Primary or Secondary
Primary
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
ZEB1
Concentration
Lot-Specific
Classification
Polyclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene Alias
[delta]EF1; 3110032K11Rik; AREB6; BOS_12951; BZP; Delta EF1; delta-crystallin enhancer binding factor 1; DELTAEF1; DELTA-EF1; FECD6; MEB1; MGC133261; Negative regulator of IL2; Nil2; NIL2A; NIL-2A; NIL-2-A; NIL-2-A zinc finger protein; OTTHUMP00000019405; posterior polymorphous corneal dystrophy 3; PPCD3; RP11-472N13.4; Tcf18; Tcf8; TCF-8; Transcription factor 8; transcription factor 8 (represses interleukin 2 expression); Tw; twirler; ZEB; Zeb1; Zfhep; Zfhx1a; Zfx1a; Zfx1ha; zinc finger E-box binding homeobox 1; Zinc finger E-box-binding homeobox 1; Zinc finger homeobox protein 1a; Zinc finger homeodomain enhancer-binding protein
Gene Symbols
ZEB1
Isotype
IgG
Purification Method
Antigen affinity chromatography
Product Type
Antibody
Related Products
Description
- ZEB1 (Zinc finger E-box-binding homeobox 1) acts as a transcriptional repressor
- It inhibits interleukin-2 (IL-2) gene expression
- ZEB1 enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and depending on the cell type
- It represses E-cadherin promoters and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1
- ZEB1 also represses BCL6 transcription in the presence of the corepressor CTBP1
- It postively regulates neuronal differentiation and represses RCOR1 transcription activation during neurogenesis
- Mutations in the gene can result in corneal dystrophy, posterior polymorphous and corneal dystrophy, Fuchs endothelial 6.