BIN1 Monoclonal Antibody (99D), Rockland™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
BIN1
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Alias
ALP-1; AMPH 2; Amph2; amphiphysin 2; Amphiphysin II; amphiphysin IIamph2; amphiphysin-like; Amphiphysin-like protein; Amphl; Bin1; BOS_1548; box dependant MYC interacting protein 1; Box-dependent myc-interacting protein 1; BRAMP-2; Bridging integrator 1; DKFZp547F068; LOC100355195; MGC10367; MGC105358; myc box dependent interacting protein 1; Myc box-dependent-interacting protein 1; SH3 domain-containing protein 9; Sh3p9
Gene Symbols
BIN1
Isotype
IgG2b
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
BIN1
Clone
99D
Applications
ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human, Mouse
Gene Accession No.
O00499, O08539
Gene ID (Entrez)
274, 30948
Immunogen
Anti-BIN1 (MOUSE) Monoclonal Antibody was produced in mouse by repeated immunizations with a fragment portion of recombinant human BIN1 protein followed by hybridoma development.
Primary or Secondary
Primary
Product Type
Antibody
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Description
- Store vial at -20°C prior to opening
- Aliquot contents and freeze at -20°C or below for extended storage
- Avoid cycles of freezing and thawing
- Centrifuge product if not completely clear after standing at room temperature
- This product is stable for several weeks at 4°C as an undiluted liquid
- Dilute only prior to immediate use
- BIN1 antibody is specific for human BIN1 protein
- A BLAST analysis was used to suggest cross-reactivity with BIN1 from human and mouse sources based on 100% homology with the immunizing sequence
- Cross-reactivity with BIN1 from other sources has not been determined
- This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor
- Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin
- Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process
- Studies in mouse suggest that this gene plays an important role in cardiac muscle development
- Alternate splicing of the gene results in ten transcript variants encoding different isoforms
- Aberrant splice variants expressed in tumor cell lines have also been described.