PD-L2/B7-DC/PDCD1LG2 Antibody (TY25) - BSA Free, Novus Biologicals™

PD-L2/B7-DC/PDCD1LG2

1.0 mg/mL

Immunohistochemistry (Frozen), Immunohistochemistry, Immunoprecipitation, Flow Cytometry

Unconjugated

Rat

Mouse

80380

B7-DC transfected RAW264.7 cells.

Primary

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

TY25

Flow Cytometry 1:100-1:200, Immunohistochemistry 1:10-1:500, Immunoprecipitation 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500

Monoclonal

Purified

RUO

B7-DC, bA574F11.2, Btdc, Butyrophilin B7-DC, CD273 antigen, CD273PD-1 ligand 2, MGC142240, PD-1-ligand 2, PDCD1L2MGC142238, PDL2B7DC, PD-L2PDCD1 ligand 2, programmed cell death 1 ligand 2, Programmed death ligand 2

PDCD1LG2

IgG2a

Protein G purified

NB100-65332 recognizes mouse CD273, a 42kD member of the B7 family, otherwise known as B7-dendritic cell (B7-DC), or programmed death ligand-2 (PD-L2). The expression of CD273 is restricted to a subpopulation of dendritic cells (DCs), and DCs and macrophages that have been stimulated with interferon gamma, GM-CSF or IL-4. CD273 has been identified as a ligand for PD-1(CD279), along with another B7 family member B7-H1 (CD274). Studies suggest that both CD273 and B7-H1 co-stimulate or inhibit T cell proliferation and cytokine production. Antibodies produced by clone TY25 are reported to block the binding of CD273 (B7-DC) to it's receptor.