Phospho-CREB (Ser133) Recombinant Rabbit Monoclonal Antibody (CREBS133-4D11), Invitrogen™
Rabbit Recombinant Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Phospho-CREB (Ser133)
Concentration
0.5 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.10% BSA, 50% glycerol and 0.02% sodium azide
Gene Alias
2310001E10Rik; 3526402H21Rik; active transcription factor CREB; AV083133; cAMP response element binding protein 1; cAMP responsive element binding protein 1; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; CREB1; Creb-1; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; cyclic AMP-responsive element-binding protein 1; htCREB; MGC9284; OTTHUMP00000206661; OTTHUMP00000206662; OTTHUMP00000206667; transactivator protein; Y protein
Gene Symbols
CREB1
Isotype
IgG κ
Purification Method
Protein A/G
Product Type
Antibody
Clone
CREBS133-4D11
Applications
Flow Cytometry, Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human, Mouse
Gene Accession No.
P16220, Q01147
Gene ID (Entrez)
12912, 1385
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser133 of human phospho CREB.
Primary or Secondary
Primary
Content And Storage
-20°C
Gene
CREB1
Related Products
Description
- CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors
- Activation of CREB is dependent upon the phosphorylation of serine 133
- Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1
- Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor
- CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133
- CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory
- In humans, the gene is located on the q arm of chromosome 2
- Diseases associated with CREB dysfunction include Alzheimer’s Disease, histiocytoma and soft tissue melanoma.