Phospho-c-Cbl (Tyr774) Recombinant Rabbit Monoclonal Antibody (CblY774-R3B8), APC, Invitrogen™
Rabbit Recombinant Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Phospho-c-Cbl (Tyr774)
Applications
Flow Cytometry
Conjugate
APC
Host Species
Rabbit
Target Species
Human, Mouse
Gene Accession No.
P22681, P22682
Gene ID (Entrez)
12402, 867
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr774 of human phospho c-Cbl.
Primary or Secondary
Primary
Content And Storage
4° C
Gene
Cbl
Clone
CblY774-R3B8
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.20% BSA and 0.09% sodium azide
Gene Alias
4732447J05Rik; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; casitas B-lineage lymphoma proto-oncogene; CBL; Cbl proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL2; Cbl-2; CBL-3; CBLC; c-Cbl; E3 ubiquitin-protein ligase CBL; FRA11B; fragile site, folic acid type, rare, fra(11)(q23.3); NSLL; oncogene CBL2; proto-oncogene c-Cbl; RGD1561386; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF55; RNF57; signal transduction protein CBL
Gene Symbols
Cbl
Isotype
IgG κ
Purification Method
Protein A/G
Product Type
Antibody
Related Products
Description
- Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation
- Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed)
- Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation
- Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.