7218717
CD157 Monoclonal Antibody (eBioSY11B5 (SY11B5)), Alexa Fluor™ 488, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
CD157
Concentration
5 μL/Test
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.2
Gene Alias
114/A10; A530073F09; ADP-ribosyl cyclase 2; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; antigen BP3; Bone marrow stromal antigen 1; bone marrow stromal cell antigen 1; Bp3; Bp-3; BP-3 alloantigen; Bst1; BST-1; Bsta1; cADPr hydrolase 2; CD157; CD157 antigen; Cyclic ADP-ribose hydrolase 2; leukocyte antigen 65; Ly65; Ly-65; NAD(+) nucleosidase; NAD+ nucleosidase
Gene Symbols
Bst1
Primary or Secondary
Primary
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Gene
Bst1
Clone
eBioSY11B5 (SY11B5)
Applications
Flow Cytometry
Conjugate
Alexa Fluor 488
Host Species
Mouse
Target Species
Human
Gene Accession No.
Q10588
Gene ID (Entrez)
683
Isotype
IgG1 κ
Purification Method
Affinity chromatography
Product Type
Antibody
Related Products
Description
- The eBioSY11B5 MAb recognizes human CD157 (Mo5, BST-1)
- CD157 is a 42-45 kDa, GPI-anchored protein with structural and functional similarities with CD38
- CD157 was initially cloned because of its expression on monocytes and macrophages, and was subsequently discovered to be the same protein named BST-1, discovered for its expression on bone marrow stromal cells and its ability to stimulate the proliferation of a mouse pre-B cell line
- CD157 is a pleiotropic ectoenzyme and is thought to act independently as an enzyme and receptor
- Similar to CD38, CD157 is involved in the metabolism of NAD+ and this activity may be involved in regulating intracellular Ca2+ levels
- As a receptor, upon binding of its putative ligand, CD157 is thought to initiate a signal transduction cascade resulting in the phosphorylation of cytoplasmic proteins including focal adhesion kinase (FAK)
- The mechanism and functional significance of CD157-initiated signal transduction remain to be fully characterized
- Bone marrow stromal cell antigen 1 (BST1) is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B cell growth
- BST1, which is also known as ADP-rybosyl cyclase 2 and DAMP-1, is an enzyme which is expressed by BST1 gene in human
- BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis
- The polyclonal B cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population.