TrkB Recombinant Rabbit Monoclonal Antibody (107), Invitrogen™
Rabbit Recombinant Monoclonal Antibody
Manufacturer: Fischer Scientific
The price for this product is unavailable. Please request a quote
Antigen
TrkB
Concentration
1 mg/mL
Classification
Recombinant Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with no preservative
Gene Alias
AI848316; BDNF/NT-3 growth factors receptor; BDNF-tropomyosine receptor kinase B; C030027L06Rik; EC 2.7.10.1; GP145 TrkB; GP145TrkB; GP145-TrkB; GP145-TrkB/GP95-TrkB; GP95 TrkB; GP95-TrkB; hyperphagia; kinase TrkB; neural receptor protein-tyrosine kinase (trkB); neurotrophic receptor tyrosine kinase 2; neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; NTRK 2; Ntrk2; OTTHUMP00000021573; OTTHUMP00000021574; OTTHUMP00000021576; OTTHUMP00000021577; RATTRKB1; Tkrb; Trk B; TRKB; trk-B; trkB protein; trkB tyrosine kinase; TRKB1; Tropomyosin-related kinase B; tyrosine kinase receptor B
Gene Symbols
Ntrk2
Isotype
IgG
Purification Method
Protein A
Product Type
Antibody
Clone
107
Applications
ELISA
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
Q16620
Gene ID (Entrez)
4915
Immunogen
Recombinant Human Trk-B protein.
Primary or Secondary
Primary
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Gene
Ntrk2
Related Products
Description
- Specificity: Human NTRK2/Trk-B NTRK2 (TRKB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system
- NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF)
- Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses
- TrkB is involved in the development and maintenance of the nervous system
- Moreover, Trk B is a tyrosine kinase gene highly related to Trk A
- Trk B expression is confined to tissues within the central and peripheral nervous systems
- The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3
- TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway
- Signaling through TrkB leads to cell differentiation
- Mutations in the TrkB gene have been associated with obesity and mood disorders
- Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.