7240816
BMP-10 Monoclonal Antibody (A1), Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
BMP-10
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
PBS with 50% glycerol and 0.05% ProClin 300
Gene Alias
BMP; BMP10; BMP-10; bmp10 {ECO:0000312; bmp10b; Bone morphogenetic protein; bone morphogenetic protein 10; EMBL:BAE16990.1, ECO:0000312; RGD:1562986}; si:dkey-13n15.5
Gene Symbols
BMP10
Isotype
IgG1 κ
Purification Method
Protein A/G
Product Type
Antibody
Clone
A1
Applications
Immunohistochemistry (Paraffin), Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Human
Gene Accession No.
O95393
Gene ID (Entrez)
27302
Immunogen
Arg315-Arg424 (Accession O95393), with N-terminal His and GST Tag
Primary or Secondary
Primary
Content And Storage
-20°C
Gene
BMP10
Related Products
Description
- Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-beta superfamily of structurally related signaling proteins
- Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life
- BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation
- It can signal through various receptor complexes usually containing BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6
- The interaction of BMP-10 with its specific receptors can induce signaling initiated by the phosphorylation of SMAD transcription factors, including SMAD1, SMAD5, or SMAD8, but can also induce SMAD independent processes
- BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration.