Uteroglobin Polyclonal Antibody, PeproTech®, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
Uteroglobin
Applications
ELISA, Western Blot
Conjugate
Unconjugated
Host Species
Rabbit
Target Species
Human
Gene Accession No.
P11684
Gene ID (Entrez)
7356
Immunogen
E.coli-derived Recombinant Human Uteroglobin
Purification Method
Antigen affinity chromatography
Gene
SCGB1A1
Concentration
0.1-1.0 mg/mL
Classification
Polyclonal
Form
Lyophilized
Regulatory Status
RUO
Formulation
PBS with no preservative
Gene Alias
Blastokinin; CC10; CC16; CCPBP; CCSP; Clara cell 17 kDa protein; clara cell phospholipid-binding protein; clara cell secretory protein; clara cells 10 kDa secretory protein; PCBB; PCB-binding protein; PCB-BP; SCGB1A1; Secretoglobin family 1A member 1; secretoglobin, family 1A, member 1 (uteroglobin); UG; Ugb; UP1; UP-1; Urinary protein 1; urine protein 1; uteroglobin; Uteroglobin (Clara cell secretory protein); Utg
Gene Symbols
SCGB1A1
Primary or Secondary
Primary
Content And Storage
-20°C
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Description
- AA Sequence of recombinant protein: MEICPSFQRV IETLLMDTPS SYEAAMELFS PDQDMREAGA QLKKLVDTLP QKPRESIIKL MEKIAQSSLC N
- Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human Uteroglobin
- Anti-Human Uteroglobin-specific antibody was purified by affinity chromatography employing an immobilized Human Uteroglobin matrix
- Sandwich ELISA: To detect Human Uteroglobin by sandwich ELISA (using 100 μL/well), a concentration of 0.5-2.0 μg/mL of this antibody is required
- This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human Uteroglobin (500-P330BT) as a detection antibody, allows the detection of at least 2000-4000 pg/mL of Recombinant Human Uteroglobin
- Western Blot: To detect Human Uteroglobin by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL
- When used in conjunction with compatible secondary reagents, the detection limit for Recombinant Human Uteroglobin is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions
- Uteroglobin, which is a member of the Secretoglobin superfamily and is also known as Clara cell phospholipid-binding protein, is a multifunctional protein that can exert anti-inflammatory and anti-tumorigenic effects by binding small hydrophobic molecules such as phospholipids and prostaglandins
- The small, non-glycosylated protein named for its high levels of expression in pre-implantation embryos, where it exhibits growth stimulatory effects, is produced and secreted by the non-ciliated, non-mucous Clara cells predominant in the epithelial surfaces of pulmonary airways, as well as other non-ciliated epithelia
- Members of the Secretoglobin superfamily demonstrate a high level of structural conservation and are characterized as small, secretory homo- or heterodimers
- In addition to sequestering pro-inflammatory mediators and carcinogens, Uteroglobin has been implicated in the inhibition of cell migration and invasion, platelet aggregation, and T cell differentiation.