AB3784PIMI
MilliporeSigma™ Adiponectin, Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | AB3784PIMI-Each-of-1 | In Stock | ₹ 41,813.09 |
AB3784PIMI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,813.09
GST (18%): ₹ 7,526.356
Total Price: ₹ 49,339.446
Antigen
Adiponectin
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ADIPOQ, ACDC, ACRP30, ADPND, APM1, GBP28
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This polyclonal antibody targets the C1q domain (globular domain) of human adiponectin.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Applications
Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q15848
Immunogen
GST-tagged recombinant human adiponectin C1q domain (globular domain) fragment.
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_004788
Target Species
Human
Related Products
Description
- Adiponectin (UniProt Q15848; also known as 30kDa adipocyte complement-related protein, ACRP30, Adipocyte complement-related 30kDa protein, Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, apM-1, Gelatin-binding protein) is encoded by the ADIPOQ (also known as ACDC, ACRP30, ADPND, APM1, GBP28) gene (Gene ID 9370) in human
- Adipokines are adipose tissue-secreted factors that are involved in vascular function and metabolic disease
- While most adipokines are proinflammatory and directly responsible for the development of the chronic inflammatory state in obesity, adiponectin is an adipokine with anti-inflammatory and insulin-sensitizing properties
- Adiponectin mediates its biological activity via adiponection receptor proteins 1 and 2 (AdipoR1 and AdipoR2)
- Both AdipoR1 and AdipoR2 are reported to be ubiquitously expressed with the highest expression in skeletal muscle and liver, respectively
- Circulating adiponectin levels are reduced in obesity and type II diabetes, whereas weight loss elevates serum levels of adiponectin
- Likewise, adiponectin overexpression is reported to alleviate metabolic dysfunction independent of weight loss in both genetic and diet-induced animal models of obesity
- Aadiponectin deficiency is associated with various clinical cardiovascular disorders including myocardial infarction, peripheral artery disease, and endothelial dysfunction
- Adiponectin is produced with a signal peptide sequence (a.a
- 1-18 in human and rat sequence; a.a
- 1-17 in mouse), which is removed postranslationally to yield the mature protein with a collagen-like domain (a.a
- 42-107 in human and rat, a.a
- 45-110 in mouse) and a C1q domain (a.a
- 108-244 in human and rat, a.a
- 111-247 in mouse).