ABD68
MilliporeSigma™ Rabbit anti-Grainyhead-Like 3/GRHL3, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABD68-Each-of-1 | In Stock | ₹ 39,338.00 |
ABD68 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,338.00
GST (18%): ₹ 7,080.84
Total Price: ₹ 46,418.84
Antigen
Grainyhead-Like 3/GRHL3
Classification
Polyclonal
Gene Accession No.
Q8TE85
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Applications
Immunocytochemistry, Immunoprecipitation, Western Blot
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
GRHL3; SOM; TFCP2L4; VWS2
Immunogen
KLH-conjugated linear peptide corresponding to an internal sequence from the C-terminal half of human Grainyhead-Like 3/GRHL3.
Quantity
100 μg
Research Discipline
Stem Cell Research
Gene ID (Entrez)
NP_937817
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
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Description
- Specifically detects Grainyhead-Like 3/GRHL3 in Human samples, and it is validated for Immunocytochemistry, Immunoprecipitation, Western Blotting Grainyhead-like protein 3 homolog (UniProt Q8TE85; also known as Sister of mammalian grainyhead, Transcription factor CP2-like 4) is encoded by the GRHL3 (also known as SOM, TFCP2L4, VWS2) gene (Gene ID 57822) in human
- Mammalian grainyhead-like (GRHL1, GRHL2, and GRHL3) genes code for transcription factors and are named after their drosophila homolog grainyhead (GRH)
- These factors show tissue- and developmental stage-dependent expression patterns
- Grainyhead-like 3 (GRHL3) is reported to play a protective role against squamous cell carcinoma (SCC) of the skin
- Tumor suppressor phosphatase and tensin homolog (PTEN) is a direct target of GRHL3, Grhl3-knockdown in mice causes skin tumor formation as a result of reduced Pten expression
- Consistently, downregulated GRHL3 and PTEN levels are found in human SCC skin samples
- In addition, GRHL3 is a positive regulator of E-cadherin expression during mesenchymal epithelial transition (MET) in non-tumorigenic mammary gland cells, as well as in breast and lung cancer cells
- High GRHL3 expression is found in early stages of breast cancer and the expression is greatly reduced in advanced stages of breast cancer.