ABS563MI
MilliporeSigma™ Rabbit anti-S1P Lyase, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABS563MI-Each-of-1 | In Stock | ₹ 40,292.08 |
ABS563MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
S1P Lyase
Classification
Polyclonal
Gene Accession No.
O95470
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Applications
Immunohistochemistry, Western Blot
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
SGPL1; KIAA1252
Immunogen
KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human S1P Lyase.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_003892
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
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Description
- Specifically detects S1P Lyase in Human samples, and it is validated for Immunohistochemistry, Western Blotting Sphingosine-1-phosphate lyase 1 (EC 4.1.2.27; UniProt O95470; also known as hSPL, S1P lyase, Sphingosine-1-phosphate aldolase, SPL 1, SP-lyase 1) is a type III single-pass ER membrane protein encoded by the SGPL1 (Also known as S1PL, SPL) gene in human (Gene ID 8879)
- SP-lyase 1 catalyzes the irreversible retro-aldol cleavage of sphingosine 1-phosphate to 2-hexadecenal and phosphoethanolamine
- S1P lyase activity knockout is reported to offer protection in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS), by preventing T cell egress from the lymph nodes into central nervous system (CNS)
- S1P lyase overexpression is also demonstrated to potentiate serum withdrawal-induced apoptosis in HEK293 cultures.