ABE1844MI
MilliporeSigma™ Rabbit anti-NRF-1, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABE1844MI-Each-of-1 | In Stock | ₹ 41,813.98 |
ABE1844MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,813.98
GST (18%): ₹ 7,526.516
Total Price: ₹ 49,340.496
Antigen
NRF-1
Classification
Polyclonal
Gene Accession No.
Q9WU00
Host Species
Rabbit
Purification Method
Protein A Purfied
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Purified
Applications
ChIP Assay, Immunocytochemistry, Western Blot
Formulation
Purified rabbit polyclonal antibody in buffer containing PBS and 0.01% Sodium Azide.
Gene Symbols
Nrf1
Immunogen
KLH-conjugated linear peptide corresponding to mouse NRF-1.
Quantity
200 μg
Research Discipline
Epigenetics and Nuclear Function
Gene ID (Entrez)
NP_001157698
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
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Description
- Specifically detects NRF-1 in Human, Mouse, Rat samples, and it is validated for Chromatin Immunoprecipitation, Immunocytochemistry, Western Blotting Nuclear respiratory factor (UniProt Q9WU00; also known as Alpha-pal, Alpha palindromic-binding protein, NRF-1) is encoded by the Nrf1 gene (also known as C87038, D6Ertd415e) in murine species (Gene ID 18181)
- NRF-1 is a redox-responsive transcription factor that plays an anti-oxidant, pro-survival role in mitochondrial biogenesis process
- NRF-1 is upregulated and activated/phosphorylated by Akt in response to oxidant exposure or increased cellular reactive oxygen species (ROS)
- This results in NRF-1 nuclear translocation, where it binds to DNA as a homodimer and mediates the transcription of mitochondrial transcription factor A (mtTFA) that is needed for mitochondrial DNA transcription.