ABE1870MI
MilliporeSigma™ anti-AHCYL1 (IRBIT), Polyclonal
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABE1870MI-Each-of-1 | In Stock | ₹ 37,825.00 |
ABE1870MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,825.00
GST (18%): ₹ 6,808.50
Total Price: ₹ 44,633.50
Antigen
AHCYL1 (IRBIT)
Classification
Polyclonal
Formulation
Purified chicken polyclonal antibody in PBS with 0.02% Sodium azide.
Gene Symbols
AHCYL1, DCAL, XPVKONA
Immunogen
Recombinant protein corresponding to human AHCYL1(IRBIT).
Quantity
100 μL
Research Discipline
Epigenetics, Nuclear Function
Gene ID (Entrez)
NP_006612
Target Species
Human
Isotype
IgY
Applications
Western Blot
Conjugate
Unconjugated
Gene Accession No.
O43865
Host Species
Chicken
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Expected to react with both spliced isoforms reported by UniProt (O43865-1 and O43865-2).
Content And Storage
2°C to 8°C for one year
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Description
- Specifically detects AHCYL1 (IRBIT) Clone: in Human samples, and it is validated for Western Blotting Putative adenosylhomocysteinase 2 (EC 3.3.1.1; UniProt O43865; also known as AdoHcyase 2, DC-expressed AHCY-like molecule, IP(3)Rs binding protein released with IP(3), IRBIT, S-adenosyl-L-homocysteine hydrolase 2, S-adenosylhomocysteine hydrolase-like protein 1) is encoded by the AHCYL1 (also known as DCAL, PPP1R78, PRO0233, XPVKONA) gene (Gene ID 10768) in human
- Originally identified by its binding and antagonist activity against teh intracellular calcium channel, IP3R, IRBIT is now known to interact with multiple targets and regulate diverse physiological events in addition to blocking IP3 access to IP3R
- IRBIT complexes with ribonucleotide reductase (RNR) in a dATP-dependent manner and stabilizes RNR in its inactive, dATP-bound state
- IRBIT also targets CaMKIIα kinase for inhibition by blocking calmodulin binding
- Other known IRBIT targets include the ion transporter NBCe1-B, the Na+/H+ exchanger NHE3, the Cl- channel CFTR, the Cl-/HCO3- exchanger Slc26a6, the Fip1 component of the cleavage and polyadenylation specificity factor (CPSF) complex
- IRBIT contains an S-adenosyl-l-homocysteine hydrolase (AHCY) homology domain in and an N-terminal extension containing a serine-rich region with multiple phosphorylation sites
- Long-IRBIT, but not IRBIT, has an additional N-terminal appendage, termed the LISN (Long-IRBIT specific N-terminal) domain
- IRBIT is highly conserved among species, and the human and mouse orthologs have 100% protein identity.