ABE1307MI
MilliporeSigma™ Rabbit anti-CHD1L, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABE1307MI-Each-of-1 | In Stock | ₹ 41,813.98 |
ABE1307MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,813.98
GST (18%): ₹ 7,526.516
Total Price: ₹ 49,340.496
Antigen
CHD1L
Classification
Polyclonal
Gene Accession No.
Q86WJ1
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Applications
Western Blot
Formulation
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
CHD1L; ALC1
Immunogen
KLH-conjugated linear peptide corresponding to the Helicase C-terminal domain of human CHD1L.
Quantity
100 μg
Research Discipline
Epigenetics and Nuclear Function
Gene ID (Entrez)
NP_004275
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Related Products
Description
- Specifically detects CHD1L in Human samples, and it is validated for Western Blotting Chromodomain helicase/ATPase DNA binding protein 1-like gene (CHD1L) is a ∼100.9kDa DNA helicase that is amplified in many solid tumors
- The CHD1L gene, located at Chr 1q21 is frequently amplified in hepatocellular carcinoma
- CHD1L plays a role in chromatin remodeling following DNA damage
- It is targeted to DNA damage sites through interaction with poly(ADP)-ribose) and regulated chromatin during DNA repair
- CHD1L contains a SNF2-N domain and a helicase superfamily domain, but unlike CHD1, it does not contain a chromodomain, but instead contains a c-terminal macrodomain, which is an (ADP)-ribose/ polymer of the ADP-ribose (PAR)-binding element
- In addition to PAR binding, the macro domain of CHD1L is able to bind Nur77, a critical member of a p53-independent apoptotic pathway
- This binding subsequently inhibits the nucleus-to-mitochondria translocation of Nur77 and disrupts apoptotic cell death
- Overexpression of CHD1L protein in tumors is considered to be an independent biomarker of poor prognosis and short tumor-free survival time.