ABF317MI
MilliporeSigma™ Rabbit anti-MICA, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABF317MI-Each-of-1 | In Stock | ₹ 42,968.31 |
ABF317MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,968.31
GST (18%): ₹ 7,734.296
Total Price: ₹ 50,702.606
Antigen
MICA
Classification
Polyclonal
Gene Accession No.
Q29983
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Applications
Immunohistochemistry, Western Blot
Formulation
Purified rabbit polyclonal in buffer containing PBS (pH 7.2) with 0.02% sodium azide.
Gene Symbols
MICA; PERB11.1
Immunogen
MICA antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human MICA.
Quantity
100 μg
Research Discipline
Inflammation and Immunology
Target Species
Human
Related Products
Description
- Specifically detects MICA in Human samples, and it is validated for Immunohistochemistry, Western Blotting The protein MHC class 1 polypeptide-related sequence A (MIC-A) and encoded by the human gene named MICA is an unusual MHC class one molecule with no known role in antigen presentation but instead acts as a stress-induced self antigen that is recognized by gamma delta T cells and is the ligand for KLRK1/NKG2D cellular receptor
- Binding to KLRK1 leads to cell lysis
- MICA is a cell membrane associated protein found in the cytoplasm
- Additionally, it is expressed in many organ systems and found expressed on many cell types
- Expression is induced by many stress responses, including infection, DNA damaging agents, E
- coli contact, hCMV and ionizing radiation
- MICA is also the antigen for many autoimmune diseases associated with the skin, one organ system where MICA is highly expressed
- Psoriasis and Psoriatic arthritis are two such diseases and antibodies to MICA have also been associated with organ transplant difficulties and allograft rejection.