MilliporeSigma™ SLC4A11, Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABN1718MI-Each-of-1 | In Stock | ₹ 40,292.08 |
ABN1718MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,292.08
GST (18%): ₹ 7,252.574
Total Price: ₹ 47,544.654
Antigen
SLC4A11
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Slc4a11, BTR1
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Specificity of this polyclonal antibody was verified by antigen peptide blocking of target band detection in Western blotting application (Jalimarada, S.S., et al. (2013). Invest. Ophthalmol. Vis. Sci. 54(6):4330-4340). Epitope sequence is conserved between murine and human (UniProt A2AJN7 and Q8NBS3) and present in all four human SLC4A11 spliced isoforms reported by UniProt.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Applications
Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody in PBS with 0.05% Sodium Azide.
Gene Accession No.
A2AJN7
Immunogen
Linear peptide corresponding to a sequence near the C-terminus of mouse SLC4A11.
Quantity
100 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_001074631
Target Species
Bovine
Related Products
Description
- Sodium bicarbonate transporter-like protein 11 (UniProt A2AJN7; also known as Bicarbonate transporter-related protein 1, NaBC1, Sodium borate cotransporter 1, Solute carrier family 4 member 11) is encoded by the Slc4a11 (also known as BTR1) gene (Gene ID 269356) in murine species
- Bicarbonate (HCO3-) transporters are the principal regulators of pH in cells and play a vital role in acid-base movement in various tissues
- There exist four types of HCO3- transporters, namely Cl-/-HCO3- exchangers, Na+/HCO3- cotransporters (NBCs), a K+/HCO3- cotransporter, and a Na+-driven Cl-/-HCO3- exchanger
- SLC4A11 is a ubiquitously expressed 14-transmembrane protein existing as dimers within the plasma membrane
- Originally classified as bicarbonate transporter, later stiudy conducted with cultured primary bovine corneal endothelial cells (BCECs) indicated that SLC4A11 mediates Na+-coupled hydroxide (OH-) transport, but not borate (B(OH)4-) or bicarbonate (HCO3-) transport in corneal endothelium
- SLC4A11 gene mutations in human are linked to endothelial dystrophies, including CDPD (Corneal dystrophy and perceptive deafness), CHED2 (Corneal dystrophy, endothelial 2, autosomal recessive), and FECD4 (Corneal dystrophy, Fuchs endothelial, 4).