ABC937MI
MilliporeSigma™ Rabbit anti-FOXL1, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABC937MI-Each-of-1 | In Stock | ₹ 42,968.31 |
ABC937MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,968.31
GST (18%): ₹ 7,734.296
Total Price: ₹ 50,702.606
Antigen
FOXL1
Classification
Polyclonal
Gene Accession No.
Q12952
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Applications
Immunohistochemistry (Paraffin), Western Blot
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
FOXL1; FKHL11; FREAC7
Immunogen
KLH-conjugated linear peptide corresponding to human FOXL1.
Quantity
100 μg
Research Discipline
Apoptosis, Cancer
Gene ID (Entrez)
NP_005241
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
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Description
- Specifically detects FOXL1 in Human samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting Forkhead box protein L1 (UniProt Q12952; also known as Forkhead-like 11, Forkhead-related protein FKHL11, Forkhead-related transcription factor 7, FREAC-7) is encoded by the FOXL1 (also known as FKHL11, FREAC7) gene (Gene ID 2300) in human
- FOXL1 protein belongs to the forehead box (Fox) family of transcription factors characterized by a common DNA-binding domain (the forkhead box)
- FOXL1 is involved in regulating the proliferation of gastrointestinal epithelial cells
- Loss of Foxl1 leads to distorted architecture of the stomach and small intestine in mice due to a markedly increased epithelial proliferation
- Foxl1 knockout is correlated with an enhanced Wnt/β-catenin pathway activation as evidenced by increased β-catenin nuclear localization
- FOXL1 expression is down-regulated in the majority of human clear cell renal cell carcinoma (ccRCC), at both mRNA and protein levels
- FOXL1 expression inversely correlates with the aggressive phenotype of ccRCC and the survival outcome of patients.