MilliporeSigma™ phospho-Keratin-18 (Ser51), Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABT1383MI-Each-of-1 | In Stock | ₹ 41,813.09 |
ABT1383MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,813.09
GST (18%): ₹ 7,526.356
Total Price: ₹ 49,339.446
Antigen
phospho-Keratin-18 (Ser51)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
KRT18, CYK18, PIG46
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This rabbit polyclonal antibody detected upregulated cellular Keratin-18 Ser52 phosphorylation upon phosphatase inhibitors treatment. The Ser52 numbering is based on keratin-18 sequence without the initiation Met1, which was removed posttranslationally.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Applications
Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P05783
Immunogen
KLH-conjugated linear peptide corresponding to human Keratin-18 target region sequence containing phosphorylated Ser52.
Quantity
100 μL
Research Discipline
Cell Structure
Gene ID (Entrez)
NP_000215
Target Species
Human
Related Products
Description
- Keratin, type I cytoskeletal 18 (UniProt P05783; also known as Cell proliferation-inducing gene 46 protein, CK-18, Cytokeratin-18, K18, Keratin-18) is encoded by the KRT18 (also known as CYK18, PIG46) gene (Gene ID 3875) in human
- Cytokeratin-18 (Keratin-18 or K18) belongs to a family of highly conserved epithelial-specific intermediate filament (IF) proteins that play an important role in the mechanical stability and integrity of epithelial cells and tissues
- Each epithelium is characterized by its unique keratin expression pattern
- All epithelial cells typically express at least one type-I and one type-II keratin, which form noncovalent heteropolymers
- Keratin 18 is a type I intermediate filament protein that pairs with keratin 8 (K8/K18) in simple epithelia and plays an important role in protecting cells from stress, injury, and apoptosis
- K18 is the only type-I keratin in adult hepatocytes and the major type-I keratin in many colonic tumor cell lines.The structure and function of K8/18 are regulated by posttranslational modifications, such as glycosylation, ubiquitination, and phosphorylation, including K8 phosphorylation on Ser8, Ser23, Ser73, Ser431, and K18 phosphorylation on Ser33 and Ser52
- K18 phosphorylation has been proposed as a progression marker for human chronic hepatitis B (CHB)
- Progressively higher Ser52 phosphorylation is reported in non-cirrhotic and cirrhotic CHB livers, and progressive increase of Ser33 and Ser52 phosphorylation correlates with the elevation of both histological lesions and enzymatic activities of alanine aminotransferase in non-cirrhotic CHB livers.