P4HTM Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | APPA6560-Each-of-1 | In Stock | ₹ 47,036.50 |
APPA6560 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,036.50
GST (18%): ₹ 8,466.57
Total Price: ₹ 55,503.07
Antigen
P4HTM
Classification
Polyclonal
Conjugate
Unconjugated
Gene
P4HTM
Gene Alias
4933406E20Rik; AI853847; BB128974; EGLN4; FLJ20262; HIFPH4; HIF-PH4; HIF-prolyl hydroxylase 4; HPH-4; hypoxia inducible factor prolyl 4 hydroxylase; hypoxia-inducible factor prolyl 4-hydroxylase; hypoxia-inducible factor prolyl hydroxylase 4; P4H TM; P4H with transmembrane domain; P4HTM; P4H-TM; PH 4; PH4; PH-4; PHD4; proline 4-hydroxylase; prolyl 4-hydroxylase, transmembrane; prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum); Prolyl hydroxlase domain-containing 4; RGD1311848; Transmembrane prolyl 4-hydroxylase
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
301008, 54681
Content And Storage
4° C, do not freeze
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Western Blot
Concentration
1 mg/mL
Formulation
tris citrate, tris phosphate with 0.09% sodium azide; pH 7-8
Gene Accession No.
Q9NXG6
Gene Symbols
P4HTM
Immunogen
The epitope recognized by this antibody maps to a region between residue 450 and the C-terminus (residue 502) of human PHD4/HIF Prolyl Hydroxylase 4 using the numbering given in entry NP_8088081 (GeneID 54681)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- This antibody does not react with mouse samples
- Suggested positive control: antigen standard for PH (transient overexpression lysate), HeLa and human glioblastoma cell lysates
- Prolyl hydroxylase 4 is a prolyl hydroxylase that modifies HIF-alpha
- Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the prolyl hydroxylase sites do not resemble those modifying collagen
- HIF is a transcriptional complex that plays a critical role in oxygen homeostasis
- Prolyl hydroxylase is an essential component of the pathway through which cells sense oxygen
- In the presence of oxygen, prolyl hydroxylases convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction
- Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis
- Prolyl hydroxylase 4, specifically, catalyzes the posttranslational formation of 4-hydroxyproline in HIF alpha proteins
- It may function as a cellular oxygen sensor and, under normoxic conditions, may targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex.