HIF1AN Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | APPA6593-Each-of-1 | In Stock | ₹ 46,591.50 |
APPA6593 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,591.50
GST (18%): ₹ 8,386.47
Total Price: ₹ 54,977.97
Antigen
HIF1AN
Classification
Polyclonal
Conjugate
Unconjugated
Gene
HIF1AN
Gene Alias
2310046M24Rik; A830014H24Rik; DKFZp762F1811; factor inhibiting HIF1; factor inhibiting HIF-1; FIH; FIH 1; FIH1; FIH-1; FLJ20615; FLJ22027; Hif1an; hypoxia inducible factor 1 alpha subunit inhibitor; hypoxia inducible factor 1 subunit alpha inhibitor; hypoxia inducible factor 1, alpha subunit inhibitor; hypoxia-inducible factor 1, alpha subunit inhibitor; hypoxia-inducible factor 1-alpha inhibitor; Hypoxia-inducible factor asparagine hydroxylase; peptide-aspartate beta-dioxygenase
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
309434, 319594, 55662
Content And Storage
4° C, do not freeze
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot
Concentration
1 mg/mL
Formulation
phosphate, tris citrate with 0.1% sodium azide; pH 7-8
Gene Accession No.
Q8BLR9, Q9NWT6
Gene Symbols
HIF1AN
Immunogen
A C-terminal region synthetic peptide made to the human FIH protein sequence (between residues 300 and the C-terminus).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Suggested positive control: antigen standard for HIF1AN (transient overexpression lysate), rat astrocytes, C6 and U251 gliomas
- Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD)
- Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator
- Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases
- Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins
- Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively
- Negatively regulates NOTCH1 activity, accelerating myogenic differentiation
- Positively regulates ASB4 activity, promoting vascular differentiation
- [UniProt]