HIF1AN Recombinant Rabbit Monoclonal Antibody (12F11), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEMA550010-Each-of-1 | In Stock | ₹ 37,202.00 |
FEMA550010 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,202.00
GST (18%): ₹ 6,696.36
Total Price: ₹ 43,898.36
Antigen
HIF1AN
Classification
Recombinant Monoclonal
Concentration
0.5 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.
Q9NWT6
Gene Symbols
HIF1AN
Immunogen
A synthesized peptide derived from human HIF1AN
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Applications
ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
12F11
Conjugate
Unconjugated
Gene
HIF1AN
Gene Alias
2310046M24Rik, A830014H24Rik, DKFZp762F1811, factor inhibiting HIF1, factor inhibiting HIF-1, FIH, FIH 1, FIH1, FIH-1, FLJ20615, FLJ22027, Hif1an, hypoxia inducible factor 1 alpha subunit inhibitor, hypoxia inducible factor 1 subunit alpha inhibitor, hypoxia inducible factor 1, alpha subunit inhibitor, hypoxia-inducible factor 1, alpha subunit inhibitor, hypoxia-inducible factor 1-alpha inhibitor, Hypoxia-inducible factor asparagine hydroxylase, peptide-aspartate beta-dioxygenase
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
55662
Content And Storage
-20°C or -80°C if preferred
Isotype
IgG
Related Products
Description
- Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD)
- Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator
- Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases
- Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins
- Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively
- Negatively regulates NOTCH1 activity, accelerating myogenic differentiation
- Positively regulates ASB4 activity, promoting vascular differentiation
- [UniProt]