DERL1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | APPA6598-Each-of-1 | In Stock | ₹ 45,968.50 |
APPA6598 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,968.50
GST (18%): ₹ 8,274.33
Total Price: ₹ 54,242.83
Antigen
DERL1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DERL1
Gene Alias
1110021N07Rik; AI195141; AW551338; Degradation in endoplasmic reticulum protein 1; DER1; DER-1; Der1-like domain family, member 1; der1-like protein 1; Derl1; derlin 1; derlin-1; DERtrin-1; RGD1311835; UNQ243/PRO276
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
103158862, 475086, 67819, 79139
Content And Storage
4° C, do not freeze
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
phosphate, tris citrate with 0.1% sodium azide; pH 7-8
Gene Accession No.
Q99J56, Q9BUN8
Gene Symbols
DERL1
Immunogen
Synthetic peptide corresponding to the C-terminal residues 200-251 of human Derlin-1.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Canine, Hamster, Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- This antibody is predicted to react with xenopus, bovine, chicken, rat, zebrafish, and mouse based on 100% sequence homology
- Suggested positive control: antigen standard for DERL1 (transient overexpression lysate), KRM (canine microsome) lysates
- Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins
- May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome
- May mediate the interaction between VCP and the degradation substrate
- In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains
- Also participates in the degradation process of misfolded cytomegalovirus US2 protein.