NPC1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | APPA6817-Each-of-1 | In Stock | ₹ 49,439.50 |
APPA6817 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,439.50
GST (18%): ₹ 8,899.11
Total Price: ₹ 58,338.61
Antigen
NPC1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
NPC1
Gene Alias
A430089E03Rik; C85354; Cdig2; D18Ertd139e; D18Ertd723e; FLJ98532; I79_014078; lcsd; Niemann Pick type C1; Niemann-Pick C disease protein; niemann-Pick C1 protein; Niemann-Pick disease, type C1; Niemann-Pick type C1; Niemann-Pick type C1 protein; nmf164; NPC; NPC intracellular cholesterol transporter 1; NPC1; sphingomyelinosis; spm; truncated Niemann-Pick C1
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
100689424, 18145, 266732, 397591, 4864
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunomicroscopy, Immunoprecipitation, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.1% sodium azide
Gene Accession No.
O15118, O35604, P56941
Gene Symbols
NPC1
Immunogen
A synthetic peptide made to the C-terminal region of human NPC1.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Hamster, Human, Mouse, Non-human Primate, Porcine, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- By Western blot, PA1-16817 detects heterogeneously glycosylated NPC1 protein with prominent bands at ∽170 and ∽220 kDa
- Suggested positive control: human fibroblast cell lysate
- Mutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by an abnormal sequestration of lipids including cholesterol and glycosphingolipids
- The NPC1 protein is a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain
- NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolyzed and released as free cholesterol
- NPC1, in addition to FTO, MC4R, and PTER has recently been shown to be a new risk loci for early-onset and morbid adult obesity in European populations.