POT1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | APPA6830-Each-of-1 | In Stock | ₹ 46,502.50 |
APPA6830 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
POT1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
POT1
Gene Alias
1500031H18Rik; AI505244; AI851169; CMM10; DKFZp586D211; Dolichyl-phosphate-mannose--protein mannosyltransferase 1; GLM9; HPOT1; mPot1; Pomt1; POT 1; POT1; POT-1; Pot1a; POT1-like telomere end-binding protein; protection of telomeres 1; protection of telomeres 1 homolog; protection of telomeres 1A; protection of telomeres protein 1; protein O-mannosyltransferase 1; Protein O-mannosyl-transferase 1; protein-O-mannosyltransferase 1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
25913
Content And Storage
4° C, do not freeze
Form
Liquid
Applications
Western Blot
Concentration
1.0 mg/mL
Formulation
tris glycine with 0.15M NaCl and 0.05% sodium azide
Gene Accession No.
Q9NUX5
Gene Symbols
POT1
Immunogen
A synthetic peptide made to an internal portion of the human POT1 protein sequence (between residues 200-300).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The target sequence has 95% sequence homology with monkey, 82% sequence homology with rat, and 72% sequence homology with mouse
- Suggested positive control: HeLa nuclear extract, antigen standard for POT1 (transient overexpression lysate)
- POT1 is a component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini
- It is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase
- Pot1 also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus
- It binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence
- Its activity is TERT dependent but it does not increase TERT activity.