Sur-2 Mouse anti-Human, Unlabeled, Clone: D27-1805, BD

Description

• SUR-2 (suppressor of ras) is a gene that was originally discovered in the vulval signaling pathway of the nematode Caenorhabditis elegans
• Genetic studies suggest that the product of the SUR-2 gene encodes a protein Sur-2, that acts downstream of the Raf/Map kinase pathway
• The human homolog of SUR-2 (hSUR-2) was shown to interact with the E1A zinc finger domain from adenovirus
• The adenovirus E1A protein can bind to a number of cellular proteins to alter cell cycle progression
• E1A exerts this change in the cell cycle by interacting with the transcriptional machinery of the cell
• In vitro studies indicate that Sur-2 interacts with the E1A zinc finger protein and the Srb/Mediator transcriptional multiprotein complex
• These studies suggest that Sur-2 may play a role as a bridge between E1A and the Srb/Mediator multiprotein complex
• However, the roles of Sur-2 in regulating the transcriptional activity of the Srb/Mediator complex and E1A remain to be fully elucidated
• Sur-2 has been reported to migrate in SDS/PAGE at 150kDa2, but our studies indicate that it migrates at approximately 140kDa
• The antibody recognizes human Sur-2
• A synthetic peptide corresponding to the N-terminus region of human Sur-2 (METQLQSIFEEVVKTEVIEC) was used as immunogen
• Host Species: Mouse Clone: D27-1805 Isotype: IgG1 κ Species Reactivity: Human Immunogen: Human Sur-2 synthetic peptide Western Blotting