CD73 Mouse anti-Rat, Unlabeled, Clone: 5F/B9, BD

Description

• The 5F/B9 antibody reacts with CD73 or Ecto-5'-nucleotidase (5'-NT), a 68-kDa GPI-anchored cell-surface protein with enzymatic and signal transduction activities
• 5'-NT catalyzes the dephosphorylation of extracellular nucleoside 5' monophosphates into a form which can enter cells to meet their metabolic needs
• It also regulates the concentration of extracellular adenosine, which initiates a variety of physiological responses through the adenosine receptors in many tissues
• Membrane-bound and/or intracytoplasmic CD73 is found in a variety of organs and tissues, including liver, kidney, adrenal cortex, spleen, muscle, nervous tissue, and heart
• The expression of CD73 on mouse leukocytes has been well characterized
• In the rat, CD73 has been detected on subsets of peripheral B and T lymphocytes, NK cells, and granulocytes, as well as bone marrow myeloid cells and some CD4+CD8- thymocytes
• The 5F/B9 mAb does not inhibit the enzymatic activity of 5’-NT
• Although soluble or plate-bound 5F/B9 mAb by itself does not affect T lymphocyte proliferation, it is an effective co-stimulator with plate-bound anti-rat CD3 mAb G4.18 (Cat
• no
• 554829).