BDB554266
FLI-1 Mouse anti-Human, Unlabeled, Clone: G146-222, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB554266-Each-of-1 | In Stock | ₹ 34,176.00 |
BDB554266 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 34,176.00
GST (18%): ₹ 6,151.68
Total Price: ₹ 40,327.68
Antigen
FLI-1
Classification
Monoclonal
Concentration
0.5mg/mL
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
Fli-1 ets Domain Fusion Protein
Quantity
0.1 mg
Research Discipline
Cell Biology
Target Species
Human
Isotype
IgG2b
Applications
Western Blot
Clone
G146-222
Conjugate
Unconjugated
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C
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Description
- Fli-1 is a 50kDa ets-related transcription factor
- Like other ets-related proteins it binds to consensus sites in DNA through an 85 amino acid ets domain in the carboxyl region of the protein
- Fli-1 is associated with Ewing sarcoma (EWS) through a t(11;22)(q24;q12) chromosomal translocation
- This translocation brings the 5' region of the EWS gene into conjunction with the 3' region of the Fli-1 gene encoding the ets-DNA binding domain
- Such a translocation is found in 85% of Ewing sarcomas
- The resulting fusion protein has the DNA binding activity of Fli- 1 and, with the EWS domain, it is also a more potent transcriptional activator than Fli-1 itself
- The strong transforming activity of the EWS-Fli-1 fusion protein may in part be due to its ability to transactivate the promoter for c-myc
- G146-222 recognizes human Fli-1
- The antibody was raised against a bacterially expressed Fli-1 ets domain fusion protein
- Host Species: Mouse Clone: G146-222 Isotype: IgG2b Species Reactivity: Human Immunogen: Fli-1 ets Domain Fusion Protein Formula Weight [Chemical]: 50kDa Immunoprecipitation, Western Blotting