BDB554450
CD121b Rat anti-Mouse, PE, Clone: 4E2, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB554450-Each-of-1 | In Stock | ₹ 35,600.00 |
BDB554450 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 35,600.00
GST (18%): ₹ 6,408.00
Total Price: ₹ 42,008.00
Antigen
CD121b
Classification
Monoclonal
Concentration
0.2mg/mL
Description
Il1r2; IL-1RII; IL-1R2; Il1rb; IL-1Rβ; IL-1R-beta; IL-1 receptor beta chain
Host Species
Rat
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
4.00E+02
Conjugate
PE
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
Mouse IL-1RII Protein
Quantity
0.2 mg
Research Discipline
Immunology
Target Species
Mouse
Isotype
IgG2a κ
Related Products
Description
- The 4E2 monoclonal antibody specifically binds to CD121b which is also known as the IL-1 receptor type II (IL-1RII, IL-1R2) or IL-1 receptor beta (IL-1R-beta, IL-1Rβ)
- CD121b is encoded by the Il1r2 gene and presents as a 68 kDa type I transmembrane glycoprotein
- It is expressed on a variety of cell types including B cells, neutrophils, monocytes, and bone marrow progenitor cells
- A soluble form of CD121b is produced by proteolysis especially after cellular activation
- Unlike the IL-1 type I receptor (CD121a), CD121b has a short cytoplasmic domain and does not mediate IL-1 signaling
- CD121b may function in a membrane or soluble form as a decoy receptor that can bind IL-1 and reduce its effective concentration and biological activity
- The 4E2 antibody blocks IL-1 binding to the IL-1 receptor type II.