BDB557404
Ly-6A/E Rat anti-Mouse, Biotin, Clone: D7, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB557404-Each-of-1 | In Stock | ₹ 13,590.30 |
BDB557404 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 13,590.30
GST (18%): ₹ 2,446.254
Total Price: ₹ 16,036.554
Antigen
Ly-6A/E
Classification
Monoclonal
Concentration
0.5mg/mL
Description
Ly-6A/E; Lymphocyte antigen 6A-2/6E-1; Ly-6A.2/Ly-6E.1; Sca-1; TAP
Host Species
Rat
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
D7
Conjugate
Biotin
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
IL-2-dependent mouse T-cell line CTL-L
Quantity
0.1 mg
Research Discipline
Immunology
Target Species
Mouse
Isotype
IgG2a κ
Related Products
Description
- The D7 antibody reacts with Ly-6A.2 and Ly-6E.1, which are allelic members of the Ly-6 multigene family
- Sca-1 (Ly6A/E), a phosphatidylinositol-anchored protein of about 18kDa, is expressed on the multipotent hematopoietic stem cells (HSC) in the bone marrow of mice with both Ly-6 haplotypes
- In mice expressing the Ly-6.2 haplotype (e.g., AKR, C57BL, C57BR, C57L, C58, DBA/2, PL, SJL, SWR, 129), Ly-6A/E is also expressed on distinct subpopulations of bone marrow and peripheral B lymphocytes and thymic and peripheral T lymphocytes
- Strains with the Ly-6.1 haplotype (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have few Ly-6A/E+ resting peripheral lymphocytes, whereas activation of lymphocytes from mice of both Ly-6 haplotypes leads to strong expression of the Sca-1 antigen
- Studies with the D7 antibody have demonstrated that Ly-6A/E may be involved in the regulation of B and T lymphocyte responses, and it appears to be required for T-cell receptor-mediated T-cell activation
- Purified E13-161.7 mAb (anti-Ly-6A/E, Mfr
- No.553333) can block binding of FITC-conjugated D7 antibody (Mfr
- No.557405) to mouse splenocytes, but purified mAb D7 is unable to block binding of FITC-conjugated E13-161.7 antibody (Mfr
- No.553335)
- Anti-Ly-6A/E (Sca-1) mAb may be used in combination with the Mouse Lineage Panel (Mfr
- No.559971) to identify HSC
- This antibody is routinely tested by flow cytometric analysis
- Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature
- Host Species: Rat Clone: D7 Isotype: IgG2a, κ Cross Reactivity: Mouse Flow Cytometry