BDB558213
GITR Rat anti-Mouse, NA/LE, Unlabeled, Clone: DTA-1, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB558213-Each-of-1 | In Stock | ₹ 61,410.00 |
BDB558213 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 61,410.00
GST (18%): ₹ 11,053.80
Total Price: ₹ 72,463.80
Antigen
GITR
Classification
Monoclonal
Concentration
1.0mg/mL
Formulation
No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered. Endotoxin level is ≤0.01 EU/μg (≤0.001 ng/μg) of protein as determined by the LAL assay.
Immunogen
Mouse CD25+ CD4+ T Cell Line
Quantity
0.5 mg
Research Discipline
Immunology
Target Species
Mouse
Isotype
IgG2b
Applications
Flow Cytometry
Clone
DTA-1
Conjugate
Unconjugated
Host Species
Rat
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C
Related Products
Description
- The DTA-1 antibody reacts with GITR [Glucocorticoid-induced Tumor necrosis factor (TNF) receptor family-Related], a 66-70kDa homodimer glycoprotein that is a member of the TNF receptor superfamily and is also known as TNFRSF18
- As its name implies, GITR expression was first detected in T lymphocytes that had been treated with dexamethasone, a glucocorticoid
- In normal naive mice, GITR is expressed at moderate levels on CD25-positive/CD4-positive/CD8a-negative thymocytes and on CD25-positive/CD4-positive/CD45RB-low splenocytes
- It is also expressed at low levels on splenic CD25-negative/CD4-positive/CD45RB-low T lymphocytes, B lymphocytes, macrophages, and dendritic cells
- Activation of T and B lymphocytes upregulates GITR expression
- GITR is a costimulatory receptor that plays an important role in Regulatory T (Treg)-cell functions, and a GITR Ligand has been detected on B lymphocytes, macrophages, and dendritic cells
- mAb DTA-1 abrogates suppression by Treg cells without affecting their proliferative response, while it is co-stimulatory for T lymphocytes that are not Treg cells
- Host Species: Rat Clone: DTA-1 Isotype: IgG2b, λ Cross Reactivity: Bovine, Mouse Blocking Assay, Flow Cytometry