BDB561272
CD279 Mouse anti-Human, PE-Cy7, Clone: EH12.1 (also known as EH12), BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB561272-Each-of-1 | In Stock | ₹ 34,888.00 |
BDB561272 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 34,888.00
GST (18%): ₹ 6,279.84
Total Price: ₹ 41,167.84
Antigen
CD279
Classification
Monoclonal
Conjugate
PE-Cyanine7
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Human PD-1 Recombinant Protein
Quantity
100 Tests
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
EH12.1 (also known as EH12)
Description
hPD-1; PD1; PDCD1; Programmed cell death 1; SLEB2
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG1 κ
Related Products
Description
- The EH12.1 monoclonal antibody specifically binds to CD279
- CD279 is an immunoregulatory receptor that is expressed on activated T cells, B cells and myeloid cells and contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region
- Mice deficient in CD279 show a breakdown of peripheral tolerance and manifest multiple autoimmune symptoms
- PD-L1 and PD-L2 are ligands of CD279 and are members of the B7 gene family
- Interaction of CD279:PD-Ligands results in inhibition of T cell proliferation and cytokine secretion
- Reports suggest that the B7/CTLA-4 pathway functions primarily to attenuate, limit, and/or terminate naοve T-cell activation in secondary lymphoid organs
- The PD-ligand:CD279 pathway, on the other hand, may primarily attenuate, limit, and/or terminate T-, B-, and myeloid cell activation/effector function at sites of inflammation in the periphery.