BDB562506
B7-H4 Mouse anti-Human, Unlabeled, Clone: MIH43, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB562506-Each-of-1 | In Stock | ₹ 18,601.00 |
BDB562506 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 18,601.00
GST (18%): ₹ 3,348.18
Total Price: ₹ 21,949.18
Antigen
B7-H4
Classification
Monoclonal
Concentration
0.5mg/mL
Description
VTCN1; VCTN1; B7 family member, H4; B7H4; B7h.5; B7S1; B7X
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG1 κ
Applications
Flow Cytometry
Clone
MIH43
Conjugate
Unconjugated
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
Recombinant human B7-H4 protein
Quantity
50 μg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C
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Description
- The MIH43 monoclonal antibody specifically binds to human B7-H4 (B7 family member, H4) that is encoded by the VTCN1 (V-set domain containing T cell activation inhibitor 1) gene
- B7-H4 is a type I membrane glycoprotein with a calculated molecular weight of 30.89 kDa
- It is also known as VCTN1, B7h.5, B7S1 (B7 superfamily member 1) or B7X
- B7-H4 is a newly discovered member of the B7 family of costimulatory proteins
- B7-H4 is not constitutively expressed on peripheral tissues
- Its expression can be induced on macrophages, dendritic cells, B cells and T cells
- By binding to its putative receptor, the function of B7-H4 was initially reported to be a negative regulator of T cell activation, proliferation and differentiation related to cytokine production and cytotoxic effector cell functions
- B7-H4 is reportedly overexpressed in a variety tumors
- B7-H4 expression by tumor macrophages appears to play a role in suppression antigen-specific T cell mediated immunity
- Recent studies indicate that B7-H4 can also be a positive regulator of T cell responses
- B7-H4 can be involved innate immunity as well, eg, by inhibiting neutrophil expansion.