BDB562576
CD195 Mouse anti-Human, Brilliant Violet 421, Clone: 2D7/CCR5, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB562576-Each-of-1 | In Stock | ₹ 27,367.50 |
BDB562576 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 27,367.50
GST (18%): ₹ 4,926.15
Total Price: ₹ 32,293.65
Antigen
CD195
Classification
Monoclonal
Conjugate
Brilliant Violet 421
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Human CCR5 Transfected Cell Line
Quantity
50 Tests
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
2D7/CCR5
Description
CCR5; C-C chemokine receptor type 5; CC-CKR-5; CKR5; CHEMR13
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG2a κ
Related Products
Description
- The 2D7/CCR5 monoclonal antibody specifically binds to the human chemokine receptor, CCR5
- CCR5 is also known as CD195
- CCR5 is a seven transmembrane-spanning G protein-associated molecule
- CCR5 belongs to the beta chemokine receptor family
- It is expressed on a subset of T lymphocytes (CD3+CD45RO+CD95+)
- CCR5 regulates lymphocyte chemotaxis activation and transendothelial migration during inflammation
- It signals a response to at least three chemokines: Regulated upon Activation Normal T-cell Expressed and Secreted (RANTES), Macrophage Inflammatory Protein-1 (MIP-1) and Monocyte Chemoattractant Protein 2 (MCP-2)
- Additionally, CCR5 has been found to be a coreceptor for macrophage-tropic HIV-1 on CD4+ cells, a characteristic that is important in viral transmission
- Reports indicate that individuals who have partial (heterozygous) or complete (homozygous) deletion of the CCR5 allele, demonstrate resistance to HIV infection
- This antibody has been shown to block ligand and gp120 binding
- It is also able to neutralize HIV infection
- The antibody was conjugated to BD Horizon™ BV421 which is part of the BD Horizon™ Brilliant Violet™ family of dyes
- With an Ex Max of 407-nm and Em Max at 421-nm, BD Horizon™ BV421 can be excited by the violet laser and detected in the standard Pacific Blue™ filter set (eg, 450/50-nm filter)
- BD Horizon™ BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue™ conjugates.