BDB564182
CD85k Mouse anti-Human, Alexa Fluor 647, Clone: ZM3.8, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB564182-Each-of-1 | In Stock | ₹ 28,791.50 |
BDB564182 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 28,791.50
GST (18%): ₹ 5,182.47
Total Price: ₹ 33,973.97
Antigen
CD85k
Classification
Monoclonal
Conjugate
Alexa Fluor 647
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG1
Applications
Flow Cytometry
Clone
ZM3.8
Description
LILRB4; ILT-3; HM18; LIRB4; LILRB5; LIR-5
Immunogen
Human ILT3 Recombinant Protein
Quantity
100 Tests
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Description
- The ZM3.8 monoclonal antibody specifically binds to CD85k which is also known as Immunoglobulin-like transcript 3 (ILT-3) and Monocyte inhibitory receptor HM18
- CD85k is encoded by LILRB4 (Leukocyte immunoglobulin-like receptor, subfamily B member 4) and is expressed as a type I transmembrane glycoprotein
- CD85k is comprised of two C2-type Ig domains, a transmembrane region, and a cytoplasmic tail with three immunoreceptor tyrosine-based inhibitory motifs (ITIMs)
- CD85k is selectively expressed by myeloid antigen presenting cells including monocytes, macrophages, and dendritic cells
- CD85k functions as an inhibitory receptor
- ILT3 can also function in antigen capture and presentation
- It is efficiently internalized upon cross-linking, and delivers its ligand to an intracellular compartment where it is processed and ultimately presented by APCs to T cells
- Thus, ILT3 is a novel inhibitory receptor that can negatively regulate activation of APCs and can be used by APCs for antigen uptake
- ILT3 expression is upregulated on tolerogenic dendritic cells that can induce regulatory T cells.